R&D Solutions for mRNA delivery platform and for antibody drug conjugate technology acquired by Debiopharm were crafted by the founder of NextGenRnD. In this video (02:47–03:44), CEO of Debiopharm, Dr. Bertrand Ducrey, talks about the impact of mRNA delivery platform R&D Solution.
Technology Readiness Level scale, TRL-scale, is an industrially applied concept that outlines the R&D steps required to progress from Basic Research to Applied Research and ultimately to Experimental Development. Basic Research maps to TRLs 1-2, Applied Research maps to TRLs 3-5, and Experimental Development starts at TRL 6.
Ready-made Solutions created by NextGenRnD contain a transition from Basic Research to Applied Research, the transition from TRL 2 to TRL 3. Our ready-made solutions are switches enabling Basic Research to Applied Research transition.
NextGenRnD ready-made Solution is:
+ formulated technology concept corresponding to at least TRL 2.
+ research proposal with: (1) detailed experimental design and approach to solve the specified R&D problem; (2) limitations and experimental plan to address them; and (3) freedom to operate analysis. These characteristics make the seamless transition to TRL 3 highly likely.
+ novel and based on experimental evidence but not yet reduced to practice;
+ interdisciplinary addressing the problem emerged, emerging, or re-emerging at the intersection of Life Sciences and at least one of the following: Chemistry, Physics, Engineering, Design, Food, Agriculture, Animal Health, or Human Health.
| Solution | No. | Labels | ||
| Rapid internalizing antibody identification platform | 1 |
Phage display, Virology, Cell biology, Design, Engineering
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| Airway smooth muscle spheroid contraction sensor platform | 2 |
Human Health, Microtissue, Microfluidics, Microscopy, High-Throughput Screening, Molecular Biology, Chemistry, Physics, Mathematics, Design, Engineering
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| Gene therapy targeting platform | 3 |
Molecular Virology, Gene Therapy, Antibody Engineering, Nanoparticle Targeting, Human Health
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| Novel drug targets for tuberculosis therapy | 4 |
Human Health, Animal Health, Microbiology, Evolutionary Biology, Systems Biology
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| Novel quantitative, robust and high-throughput assay for monitoring tau protein aggregation | 5 |
Protein Engineering, Biophysics, High-Throughput Screening, Alzheimer's Disease, Tauopathies, Human Health
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| Next generation muscle targeting platform | 8 |
Antibody Engineering, Phage Display, Targeting Moiety Minimization, Rational Design, Disease Model, Human Health
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| Longitudinal detection and quantification of intrathecally-injected antisense oligonucleotides in brain using intravenously delivered probe | 9 |
ASO detection and quantification in CNS, Design, Engineering, Chemical Biology, Human Health
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| Protection of thermally sensitive proteins added to poultry and swine feed | 10 |
Animal Feed, Swine, Poultry, Fluidized bed spraying, Encapsulation, Release, One Health
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| Galvanized virus – determine the lipid composition of every virion in a virus sample population | 11 |
Galvanized Virus, Design, Engineering
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| Systemic therapeutic peptide delivery via gastrointestinal tract | 12 |
Protein Engineering, Gastrointestinal-to-Systemic Delivery, Rational Design, Human Health
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| Lawsonia intracellularis propagation – a large-scale intracellular pathogen cultivation model | 13 |
Swine, Lawsonia intracellularis, Cultivation, Attenuation, Vaccine, Enteropathy/Ileitis, Prevention and Control, Rational Design, One Health
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| RNA Interference Aided Long-Term Culture of Dirofilaria immitis Third Stage Larvae | 14 |
Dog, Heartworm, Dirofilaria immitis, L3 stage, Culturing, Prevention and Control, Rational Design, One Health
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| Universal Pipeline for the Extraction of Nucleic Acids, Polysaccharides, and Proteins from Spent Microbial Biomass | 17 |
Fermentation waste, Spent Microbial Biomass, Valorization, Extraction, Nucleic Acids, Proteins, Polysaccharides, Process Engineering, Aquaculture Health, Animal Health, Human Health
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| Next Generation Controlled Release Fertilizer (NextGenCRF) | 19 |
Controlled Release Fertilizer, Biodegradable, Engineering
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Thank you for your proposal which has been selected as the best one. The solution proposed will cover and is compatible with all small antibody formats defined in the Challenge with no anticipated impact on the antigen-binding site.
The solution is very effective under laboratory conditions.
We were impressed by the description of the in vitro model and the level of detail provided, including the research plan as well as the underlying expertise.
The solution was detailed in the process, modeling and principles of attenuation.
The solution is very complete and innovative.
The solution was extremely detailed and well planned.